This 2016 video from the USA says about itself:
There are many scientific studies that apply traditional approaches to ecological, physiological, and molecular research questions. However, these studies largely test these questions at only a single level of the biological hierarchy (microscopic to macroscopic). The Systems Science in Marine Biology (SSiMBio) group at Oregon State University believes that a broader, systems view is needed in order to make progress as it provides a powerful framework for understanding how the processes occurring at some biological levels lead to predictable outcomes at other levels. Our group is developing the temperate symbiotic sea anemone Anthopleura elegantissima as a model system for this systems biology approach. This video encapsulates the meaning and goals of our group by showing many different aspects of this system on many biological levels.
From the Institut Pasteur in France:
The sea anemone, an animal that hides its complexity well
July 9, 2018
Despite its apparent simplicity — a tube-like body topped with tentacles -, the sea anemone is actually a highly complex creature. Scientists from the Institut Pasteur, in collaboration with the CNRS, have just discovered over a hundred different cell types in this small marine invertebrate as well as incredible neuronal diversity. This surprising complexity was revealed when the researchers built a real cell atlas of the animal. Their findings, which will add to discussions on how cells have diversified and developed into organs during evolution, have been published in the journal Cell.
The sea anemone Nematostella vectensis provides a perfect model for researchers — apart from its stinging tentacles perhaps. It is a small marine invertebrate that is easy to keep in the laboratory and whose genome is simple enough to study its workings and close enough to that of humans for conclusions to be drawn. “When the sea anemone genome was sequenced in 2007, scientists discovered that it was very similar to the human genome, both in terms of the number of genes (roughly 20,000) and its organization, explains Heather Marlow, a specialist in developmental biology in the (Epi)genomics of Animal Development Unit at the Institut Pasteur and the main author of this study. These similarities make the sea anemone an ideal model for studying the animal genome and understanding interactions existing between genes.” It also has another advantage — its strategic position in the tree of life. The cnidaria branch that anemones belong to separated from the bilateria branch, in other words from most other animals, including humans, over 600 million years ago. “The anemone can therefore also help us to understand the origin and evolution of the multiple cell types making up the bodies and organs of animals, and particularly their nervous systems”, sums up Heather Marlow.
To try and understand a little more about sea anemones — and consequently about the whole animal kingdom -, Heather Marlow’s team decided to examine this cnidarian, cell by cell. Thanks to an innovative technique, the animal’s tiny cells — that measure no more than 1 micron in diameter — were isolated one by one, and their RNA analyzed. As although chromosomal DNA contains all genes, RNA shows those that are active. “The development of genome approaches at single-cell level can be used to accurately list the different cell types and also identify the genes responsible for the function of each of these cells”, explains Heather Marlow. In total, and unexpectedly, over a hundred different cell types were identified, grouped into eight main cell families (muscle, digestive, neuronal, epidermal, etc.). And one of the greatest surprises of this research concerns the nervous system. Close to thirty different types of neurons — peptidergic, glutamatergic or even insulinergic — were identified, revealing a relatively complex nervous and sensory system.
This research should therefore help evolution specialists to establish the common ancestor of cnidaria (anemones) on the one hand and bilateria (humans) on the other. Undoubtedly this ancestor already had some level of cell complexity. In addition, even though the sea anemone appears to be very different from us, it reveals the fundamental rules that today enable its cells, and our own, to perform so many different functions. “The cell is the basic element making up living beings.” By defining how the information coded by the genome determines the identity of each cell, we hope to uncover the mechanisms conserved by all animals that are essential for their development and homeostasis”, concludes Heather Marlow.